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KMID : 1123920100240020290
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 2 p.290 ~ p.295
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( Inhibitory Effect of Gamigunggui-tang on Allergic Contact Dermatitis )
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Ahn Ji-Young
Im Lee-Rang
Kim Jun-Ho
Xin Mingjie
Kwon Se-Uk
Kim Dae-Keun
Song Bong-Suk
Song Bong-Jun
Jung Hyun-Ju
Hong Seung-Heon
Kwon Dong-Yeul
Kim Yun-Kyung
Kim Dae-Ki
Lee Young-Mi
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Abstract
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Gamigunggui-tang (GMGGT) is one of the important prescriptions that has been used in oriental medicine. We investigated the inhibitory effect of an oral administration of hot water extract of GMGGT on the development of atopic dermatitis (AD) by using Balb/c mice. The induction of atopic dermatitis-like lesion was conducted by the removal of the back hairs and topical application of 2,4-Dinitrochlorobenzene (DNCB) on to the back skin repeatedly. GMGGT was orally administered at a different dose (10.0 mg/kg, 50.0 mg/kg). Skin reactions, consisting of increased ear thickness and the presence of ear inflammation, were observed in mice over three weeks. Oral administration of GMGGT significantly suppressed the skin lesions, ear swelling, spleen weight, total serum IgE in a concentration dependent manner, and also inhibited the infiltration of mast cells in the dorsal skin. In the present study, these results suggested that GMGGT extract inhibits inflammatory response atopic dermatitis. Therefore, GMGGT may be effective substances for the management of AD in human.
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KEYWORD
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Gamigunggui-tang, atopic dermatitis, mast cells, IgE, 2, 4-Dinitrochlorobenzen
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